Searchable abstracts of presentations at key conferences in endocrinology

ea0028oc1.3 | Young Endocrinologists prize session | SFEBES2012

Effect of selenium status on the skeleton in post-menopausal women: the OPUS study

Gogakos Apostolos , Hoeg Antonia , Murphy Elaine , Mueller Sandra , Reid David , Gluer Claus , Felsenberg Dieter , Roux Christian , Eastell Richard , Koehrle Josef , Schomburg Lutz , Williams Graham

T3-action is regulated by three iodothyronine deiodinases, which contain selenium in the active site. It is proposed that Se availability regulates thyroid function. OPUS is a European population-based prospective cohort study of post-menopausal women in which we showed thyroid function within the upper normal range is associated with reduced bone mineral density (BMD) and increased non-vertebral fracture risk. Using strict exclusion criteria we defined reference ranges for th...